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Chiral Selectors

Daicel Protein-based Chiral Selectors

Daicel immobilized protein stationary phases are successfully used by scientists for separation and characterization of chiral compounds across a wide range of applications—from drug discovery and quality assurance to environmental monitoring and drug-protein binding studies.

Broad enantioselectivity

Daicel CHIRALPAK® protein-based chiral selectors are immobilized on 5-µm spherical silica particles. They function entirely in the reversed-phase chromatographic mode, using buffers with low organic modifier content and at moderate pH values. Enantioselectivity can easily be controlled or improved by changes in the mobile phase composition: pH, buffer and organic modifier types and concentrations

image of Blue Daical CHIRALPAK for achiral chromatography and Zwitterionic

Multiple selectors, many applications

Daicel protein stationary chiral selectors are available with three main proteins:

  • CHIRALPAK® AGP – α 1-acid glycoprotein
  • CHIRALPAK® HSA – Human serum albumin
  • CHIRALPAK® CBH – Cellobiohydrolase (stable enzyme)

The Daicel CHIRALPAK® AGP selector has extremely broad applicability for the separation of a wide variety of chiral compounds, such as amines, acids, and nonprolytes. The enantioselectivity of the Daicel CHIRALPAK® CBH selector is complementary to that of the AGP selector.

A range of other serum albumin protein columns is available for use alongside CHIRALPAK® HSA in binding studies to confirm the ability of a pharmaceutical to bind to a protein, including:

  • CHIRALPAK® RSA – Rat serum albumin
  • CHIRALPAK® BSA – Bovine serum albumin
  • CHIRALPAK® MSA – Mouse serum albumin
  • CHIRALPAK® PSA – Pig serum albumin
  • CHIRALPAK® DSA – Dog serum albumin

View our Protein-based chiral selectors brochure

See tips for column care

Download our Chiral Selectors Poster

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