CHIRALPAK® ZWIX(+) and CHIRALPAK® ZWIX(-) are two chiral columns packed with zwitterionic chiral stationary phases (CSPs). The novel ZWIX selectors are zwitterionic molecules that incorporate both anion- and cation-exchange functional groups. The CHIRALPAK® ZWIX columns were developed for the separation of zwitterionic molecules, such as underivatized amino acids and small peptides, although numerous other separations of challenging molecules have been reported.
To learn more about the ZWIX selectors, columns, and their applications, click here.
Anion Exchange Columns
CHIRALPAK® QN-AX and CHIRALPAK® QD-AX are two chiral columns packed with weak anion-exchange (AX) CSPs. The novel selectors for CHIRALPAK® QD-AX and CHIRALPAK® QN-AX are based on complementary quinine (QN) and quinidine (QD) derivatives. The CHIRALPAK® QN-AX and CHIRALPAK® QD-AX were designed for the separations of chiral acids, such as N-derivitized amino acids and phenols.
To learn more about the QN-AX and QD-AX selectors, columns, and their applications, click here.
Crown Ether Columns
CROWNPAK® CR(+) and CROWNPAK® CR(-) are two chiral columns packed with chiral crown ether CSPs. CROWNPAK® CR(+) and CROWNPAK® CR(-) were designed for the separation of chiral amino acids and other small molecules containing a primary amine group on the chiral center.
CROWNPAK® CR-I(+) and CROWNPAK® CR-I(-) contain identical selectors to their coated CROWNPAK® CR(+) and CROWNPAK® CR(-) analogs, however the selectors are immobilized to their silica support. Immobilization extends the range of solvents used for mobile phases, thereby enhancing enantioselective resolution of chiral compounds.
New Amino Acid Database
Be sure to view our database of enantioseparations of α-proteinogenic, unusual α-, β-, and γ-amino acids, and their derivatives on CHIRALPAK® ZWIX, CHIRALPAK® QN/QD-AX, CROWNPAK® CR (+)/(-), and macrocyclic glycopeptide chiral stationary phases.
This collection of data was supplied by Prof. Antel Peter, University of Szeged, Department of Inorganic and Analytical Chemistry. We thank Prof. Peter for his contributions to the community, the original publications containing these chiral separations, and the time and dedication required to combine these efforts into a single collection.
Ligand Exchange Columns
CHIRALPAK® WH and CHIRALPAK® MA(+) contain proline and N,N-dioctyl-L-alanine, respectively, as their chiral selectors. CHIRALPAK® WH and CHIRALPAK® MA(+) are ligand-exchange type columns that can be used with aqueous solutions of copper sulfate (0.1 to 2mM). These columns were designed for alpha amino acids and other acidic chiral molecules.
We provide detailed Instruction Manuals containing column descriptions, operating conditions, and guidelines for method development. Exercising good column care is important for column performance.